Meeting with Nobel laureate Sir Peter Ratcliffe 

Understanding cellular oxygen sensing mechanisms:
adventures of a physician in discovery science

March 16, 2023, 13:30-15:00
Auditorium A+B, UW Center for Biological and Chemical Sciences, ul. Żwirki i Wigury 101, 02-089 Warsaw

You are cordially invited to attend a unique event – a meeting with Sir Peter Ratcliffe, winner of the 2019 Nobel Prize in Physiology or Medicine, who was honored for his contribution to the discovery of how cells sense and adapt to the availability of oxygen.

Abstract: The maintenance of oxygen homeostasis is a fundamental physiological challenge, inadequate oxygen (hypoxia) being a major component of most human diseases. The lecture will trace insights into human oxygen homeostasis from the founding work of William Harvey on the circulation of the blood to the molecular elucidation of a system of oxygen sensing that functions to measure oxygen levels in cells and control adaptive cellular and systemic responses to hypoxia. It will describe how work that commenced with studies of the regulation of the erythropoietin (EPO) gene by blood oxygen availability led to the unexpected discovery that the underlying oxygen sensitive process is present in all animal cells. The lecture will outline how the actual oxygen sensitive signal is generated by a set of ‘oxygen splitting’ enzymes that modify the key transcription factor (HIF) to signal its degradation (and hence inactivation) in the presence of oxygen.  It will attempt to illustrate and rationalize the unexpected in biological discovery and discuss the interface of discovery science with the development of medical therapeutics.

The meeting will be conducted in English. We do not provide for simultaneous translation. Registration for the event is required.

In addition, we would like to inform you that during the course of the project, photos and audio and video recordings will be taken, which may be published on social media and on websites in the domain of the University of Warsaw and the other organizers of the event, Nobel Prize Outreach and AstraZeneca.

Fields marked with * are required.

PLEASE NOTE – we are currently accepting registrations only for the reserve list, i.e. no guaranteed seating.

___

ENG version

Take part in a unique event – a meeting with Sir Peter Ratcliffe, winner of the Nobel Prize in Physiology or Medicine in 2019, who was honored for his discoveries of how cells sense and adapt to oxygen availability.

The meeting will be held in English. We do not provide simultaneous translation. Please register for the event.

In addition, we would like to inform you that photos and audio and video recordings will be taken during the meeting, which may be published in social media and on websites in the domain of the University of Warsaw and other organizers of the event, Nobel Prize Outreach and AstraZeneca.

Fields marked with * are required.

PLEASE NOTE – we are currently accepting registration only on the reserve list, i.e. without guaranteed seats.